Panathinaikos host Olympiakos in the fiercest derby of the Greek Super League.
Olympiakos go to Leoforos having an eight-point lead at the top of the table and a win over their rivals will secure them the Super League title for yet another season.
For Panathinaikos this derby is a must-win to retain their title hopes as Andrea Stramaccioni is set to make his debut as Panathinaikos manager.
Michael Essien is in contention for the first time since he joined Panathinaikos over the summer, however he is due to start from the bench.
Olympiakos will not have Chori Dominguez and Alberto Botia available as both struggle with injury problems.