PAOK beat 3-1 Panathinaikos to add more misery for the Greens.
The home side managed to establish their three-goal lead during the first half. Berbatov opened the score from the penalty spot in the 28th minute and three minutes later Rodrigues doubled PAOK's lead.
Just before the break PAOK killed the game off as Miguel Vitor made it 3-0 with a powerful header.
It was too little too late for Panathinaikos who just managed to score the consolation goal with Nikos Karelis from the penalty spot in the 74th minute.
This defeat was a huge blow for Panathinaikos as they stay six points adrift Olympiakos at the top of the table.